WEST
AFRICAN FRUIT STOPS EBOLA VIRUS IN LAB EXPERIMENTS - BITTER KOLA SUCCEEDED IN
THE TEST TUBE.
INQUIRER WASHINGTON BUREAU
ST. LOUIS
— A bitter fruit traditionally used as a daily health tonic in West Africa
stopped the Ebola virus in test tubes in initial laboratory experiments, and
may also work against the flu, experts announced yesterday.
In West
Africa, Garcinia kola - called bitter kola - is used daily as a near-cure-all
for everything from the flu to hangovers, and is even marketed as an
antioxidant dietary supplement in the United States.
A
Nigerian with an odd combination of folk-remedy expertise and a doctorate in
Western pharmacology has connected the golf-ball-size nut to Ebola, the mostly
fatal infectious disease that scares doctors worldwide.
"From
the same African forest where we identified Ebola, we can have a cure,"
Maurice Iwu, executive director of the Bioresources Development and
Conservation Programme, and a consultant at Walter Reed Army Hospital in
suburban Washington, said at the 16th International Botanical Congress in St.
Louis. Ebola struck about 1,000 people between 1976 and 1995 in Africa.
One of
the top infectious-disease labs in the United States tested the fruit, and said
that it passed the crucial and difficult first hurdle.
"It
certainly is a promising compound," said John Huggins, a virus expert who
heads the effort at the U.S. Army Medical Research Institute of Infectious
Diseases in Fort Detrick, Md., to find antiviral drugs to fight exotic
diseases. "So far, it's made it through all the gates that it has been
sent through."
But there
are many more tests to be done, first on mice in the next few months, and
eventually primates, before it would be used on people, Huggins said.
Only one
of 20 prospective drugs that pass the test-tube test makes it onto the market,
so the odds are against the fruit, Huggins said.
"I
would be - and am - very skeptical," Lawrence Gelb, a professor of
microbiology at Washington University in St. Louis, said. "But you can't
be an outright cynic; eventually some [prospective drug] works."
The
reason bitter kola may have an edge over other types of drugs that work in lab
tests is that many drugs often prove toxic to people and animals in subsequent
testing, whereas bitter kola has been used for centuries, and has gotten
federal approval as a safe dietary supplement, said Jim Miller, head of applied
research at Missouri Botanical Garden, who has tried to develop plants as
medicine in the past.
A handful
of other drugs have made it this far in fighting Ebola, but they are not from
natural plants and may eventually flunk the toxic test, Huggins said.
"Even
in megadoses, [bitter kola] doesn't possess any toxins," Iwu said. He said
that West Africans use the fruit as "a welcoming gift" despite its
bitter taste, because it seems to work for a variety of health problems.
Iwu does
not like hearing it called a miracle drug. "This is not a miracle
drug," he said. "This is a drug that we are using that we found a new
application for."
What Iwu
and Huggins think makes bitter kola - which can be bought in West African
markets - work is a form of the chemical compound flavonoids, which are thought
to have anti-infective properties. Bitter kola has biflavonoids, which are two
flavonoids fused together.
"Aspirin
started out as a folk remedy; quinine started out as a folk remedy,"
Huggins said. "Those were folk remedies because they actually work."
so if you so want to avoid Ebola disease, start eating bitter cola now.
Breaking News : scientists discover cure for Ebola Virus
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